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Insomnia is certainly the most frequent adverse event and it could be avoided by taking the first dose of bupropion early in the morning and the second dose in the late afternoon, at least 4 h prior bedtime

But nicotine remains addictive, and dependence can develop just as easily as with cigarettes or vapes

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Tobacco smoke contains 100 known carcinogens, and 900 potentially cancer-causing chemicals, none of which has been found in more than trace quantities in e-cigarette vapor

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